Tamarix dioica (Ghaz) Protective Potential in the Carbon Tetrachloride-Induced Hepatotoxicity Animal Model

Introduction: Hepatic diseases remain the leading cause of death worldwide. Despite overall advancements in health care, mortality due to hepatic is constantly growing. More than 2 million people globally are estimated die each year from liver diseases, and current treatment offers little for its management. Thus, it essential find more effective less toxic pharmaceutical alternatives diseases. Aims & Objectives: Tamarix dioica, a shrub broadly used herbal medicine prevention various The study was designed analyze hepatoprotective effect T. dioica BALB?cmice against CCl4-induced acute damage. Place duration study: conducted NIH, Islamabad, Pakistan, six months 2016-2017. Material Methods: For vivo evaluation, animals (n= 42) were randomly divided into seven groups (n=6), three control (i.e. Group, I or normal control, group II induction received 0.9% saline orally, Group III positive silymarin 100 mg/kg per oral), four IV, V,VI VII treated with oral T.dioica 200 mg/kg/day, 300mg/kg/day methanol extract, 200mg/kg/day aqueous extracts respectively days, followed by intraperitoneal administration CCl4 on seventh day. blood samples collected analysis LFTs, tissue taken histological analysis. Data analyzed using SPSS version 16, one-way ANOVA Duncan’s Multiple Range Test (DMRT). Results: resulted severe derangement manifested as highly elevated mean LFTs (ALT 7245.56, AST 3292.11, ALP 340.09 U/L, bilirubin 4.64 mg/dl) compared healthy controls 38.97, 50.20, 57.17 1.25 mg/dl: (Group 1) levels p<0.001. Pretreatment different 6 days before produced varying degrees hepatoprotection. 300mg/kg extract (Group7) prevented damage maximal hepatoprotection, reduced (ALT: 339.95 , AST: 242.90 ALP: 116.86 bilirubin: 1.38 normalized histology standard drug 100mg/kg, 6483.23, 2567.69, 272.19 2.84 3) Lesser hepatoprotection provided 200mg/kg 439.93, 367.87, 180.62 U/L 1.53 VI) least methanolic Groups V IV 6338.06, 6443.91, 2800.81, 3012.34, 242, 248 2.82 3.62 respectively. Further, no drug-induced toxicity symptoms observed 24 hours after high dose 2000 mg/kg/body weight administered. Conclusion: especially CCl4-mediated damage, ameliorated histopathological well biochemical parameters free 2000mg/kg /body mice experimental model. has potential research.